Lookup NU author(s): Dr Carmen Martin-Ruiz,
Professor Thomas von Zglinicki
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
Telomere length is hypothesised to be a biological marker of both cognitive and physical ageing. Here we measure telomere length, and cognitive and physical abilities at mean ages 70, 73 and 76 years in the Lothian Birth Cohort 1936 (LBC1936), and at mean ages 79, 87, 90 and 92 years in the Lothian Birth Cohort 1921 (LBC1921). We investigate whether telomere length change predicts change in cognitive and physical abilities. In LBC1936 telomere length decreased by an average of 65 base pairs per year and in LBC1921 by 69 base pairs per year. However, change in telomere length did not predict change in cognitive or physical abilities. This study shows that, although cognitive ability, walking speed, lung function and grip strength all decline with age, they do so independently of telomere length shortening. (C) 2016 The Authors. Published by Elsevier Ireland Ltd.
Author(s): Harris SE, Marioni RE, Martin-Ruiz C, Pattie A, Gow AJ, Cox SR, Corley J, von Zglinicki T, Starr JM, Deary IJ
Publication type: Article
Publication status: Published
Journal: Mechanisms of Ageing and Development
Print publication date: 01/03/2016
Online publication date: 10/02/2016
Acceptance date: 05/02/2016
Date deposited: 06/06/2016
ISSN (print): 0047-6374
ISSN (electronic): 1872-6216
Publisher: Elsevier Ireland
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