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Cell-Targeted Optogenetics and Electrical Microstimulation Reveal the Primate Koniocellular Projection to Supra-granular Visual Cortex

Lookup NU author(s): Professor Michael SchmidORCiD

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Abstract

Electrical microstimulation and more recently optogenetics are widely used to map large-scale brain circuits. However, the neuronal specificity achieved with both methods is not well understood. Here we compare cell-targeted optogenetics and electrical microstimulation in the macaque monkey brain to functionally map the koniocellular lateral geniculate nucleus (LGN) projection to primary visual cortex (V1). Selective activation of the LGN konio neurons with CamK-specific optogenetics caused selective electrical current inflow in the supra-granular layers of V1. Electrical microstimulation targeted at LGN konio layers revealed the same supra-granular V1 activation pattern as the one elicited by optogenetics. Taken together, these findings establish a selective koniocellular LGN influence on V1 supra-granular layers, and they indicate comparable capacities of both stimulation methods to isolate thalamo-cortical circuits in the primate brain.

Publication metadata

Author(s): Klein C, Evrard HC, Shapcott KA, Haverkamp S, Logothetis NK, Schmid MC

Publication type: Article

Publication status: Published

Journal: Neuron

Year: 2016

Volume: 90

Issue: 1

Pages: 143-151

Print publication date: 06/04/2016

Online publication date: 24/03/2016

Acceptance date: 08/02/2016

ISSN (print): 0896-6273

ISSN (electronic): 1097-4199

Publisher: Cell Press

URL: http://dx.doi.org/10.1016/j.neuron.2016.02.036

DOI: 10.1016/j.neuron.2016.02.036

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