Lookup NU author(s): Dr Edward Merricks,
Professor Andrew Trevelyan
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The extensive distribution and simultaneous termination of seizures across cortical areas has led to the hypothesis that seizures are caused by large-scale coordinated networks spanning these areas. This view, however, is difficult to reconcile with most proposed mechanisms of seizure spread and termination, which operate on a cellular scale. We hypothesize that seizures evolve into self-organized structures wherein a small seizing territory projects high-intensity electrical signals over a broad cortical area. Here we investigate human seizures on both small and large electrophysiological scales. We show that the migrating edge of the seizing territory is the source of travelling waves of synaptic activity into adjacent cortical areas. As the seizure progresses, slow dynamics in induced activity from these waves indicate a weakening and eventual failure of their source. These observations support a parsimonious theory for how large-scale evolution and termination of seizures are driven from a small, migrating cortical area.
Author(s): Smith EH, Liou JY, Davis TS, Merricks EM, Kellis SS, Weiss SA, Greger B, House PA, McKhann GM, Goodman RR, Emerson RG, Bateman LM, Trevelyan AJ, Schevon CA
Publication type: Article
Publication status: Published
Journal: Nature Communications
Print publication date: 01/03/2016
Online publication date: 29/03/2016
Acceptance date: 19/02/2016
ISSN (electronic): 2041-1723
Publisher: Nature Publishing Group
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