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Enhanced cytocompatibility and functional group content of poly(L-lysine) dendrimers by grafting with poly(oxazolines)

Lookup NU author(s): Professor Mike Waring

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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).


Abstract

When considering the design of an advanced drug delivery system, a common desirable attribute is to have a prolonged residence time in blood circulation so that accumulation and localised payload release may occur at the site of interest (e.g. a tumour). Polyethylene glycol (PEG) has been a gold standard for fulfilling this requirement, and consequently has been well investigated as a material for surface modification of dendrimers. As an alternative, we have explored the use of polyoxazolines (POZ)s as materials for modifying the surface of a generation 5 L-lysine dendrimer and found that there was a significant improvement in the biocompatibility properties over the unmodified dendrimer. One particularly useful advantage of POZ over PEG lies in the main-chain pendant groups available that we were able to exploit to impart functionality. Modifying the POZ to have pendant carboxyl groups led to a novel modified dendrimer with significantly more sites for conjugation. With this, we have demonstrated a sixfold increase in the loading of coumarin (our model compound) when compared to a non-functional POZ equivalent.


Publication metadata

Author(s): England RM, Hare JI, Kemmitt PD, Treacher K, Waring MJ, Barry ST, Alexander C, Ashford M

Publication type: Article

Publication status: Published

Journal: Polymer Chemistry

Year: 2016

Volume: 7

Issue: 28

Pages: 4609-4617

Print publication date: 28/07/2016

Online publication date: 20/05/2016

Acceptance date: 18/05/2016

Date deposited: 01/06/2016

ISSN (print): 1759-9954

ISSN (electronic): 1759-9962

Publisher: Royal Society of Chemistry

URL: http://dx.doi.org/10.1039/c6py00478d

DOI: 10.1039/C6PY00478D


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