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Lookup NU author(s): Dr Sean Colloby, Dr Greg Elder, Professor John O'Brien, Professor John-Paul TaylorORCiD
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
ObjectivesSeveral cholinergic nuclei, and in particular the nucleus basalis of Meynert, are localised to the substantia innominata in the basal forebrain. These nuclei provide major cholinergic innervation to the cerebral cortex and hippocampus, and have an essential role in cognitive function. The aim of this study was to investigate volumetric grey matter (GM) changes in the substantia innominata from structural T1 images in Alzheimer's disease (AD), dementia with Lewy bodies (DLB) and healthy older participants using voxel-based morphometry.MethodsParticipants (41 DLB, 47 AD and 39 controls) underwent 3 T T1 magnetic resonance imaging and cognitive assessments. Voxel-based morphometry analysis used SPM8 with a substantia innominata brain mask to define the subspace for voxel GM analyses. Group differences, and selected behavioural and clinical correlates, were assessed.ResultsCompared with that in controls, bilateral GM loss in the substantia innominata was apparent in both AD and DLB. Relative to controls, significant bilateral GM loss in the substantia innominata was observed in DLB and AD. In DLB, significant associations were also observed between substantia innominata GM volume loss, and the levels of cognitive impairment and severity of cognitive fluctuations.ConclusionsRelative to that controls, atrophy of the substantia innominata was apparent in DLB and AD, and is associated with specific clinical manifestations in DLB
Author(s): Colloby SJ, Elder GJ, Rabee R, O'Brien JT, Taylor J-P
Publication type: Article
Publication status: Published
Journal: International Journal of Geriatric Psychiatry
Year: 2017
Volume: 32
Issue: 6
Pages: 615-623
Print publication date: 01/06/2017
Online publication date: 19/05/2016
Acceptance date: 19/04/2016
Date deposited: 27/06/2016
ISSN (print): 0885-6230
ISSN (electronic): 1099-1166
Publisher: John Wiley & Sons Ltd
URL: http://dx.doi.org/10.1002/gps.4500
DOI: 10.1002/gps.4500
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