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The role of micronutrients in the risk of urinary tract cancer

Lookup NU author(s): Dr Jakub Bukowczan

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Abstract

Prostate, bladder and kidney cancers remain the most common urological malignancies worldwide, and the prevention and treatment of these diseases pose a challenge to clinicians. In recent decades, many studies have been conducted to assess the association between supplementation with selected vitamins and elements and urinary tract tumour initiation and development. Here, we review the relationship between vitamins A, B, D, and E, in addition to calcium, selenium, and zinc, and the risk of developing prostate, kidney and bladder cancer. A relatively consistent body of evidence suggests that large daily doses of calcium (> 2,000 mg/day) increase the risk of prostate cancer. Similarly, supplementation with 400 IU/day of vitamin E carries a significant risk of prostate cancer. However, there have been many conflicting results regarding the effect of these nutrients on kidney and bladder neoplasms. Moreover, the role of other compounds in urinary tract carcinogenesis needs further clarification.

Publication metadata

Author(s): Golabek T, Bukowczan J, Sobczynski R, Leszczyszyn J, Chlosta PL

Publication type: Article

Publication status: Published

Journal: Archives of Medical Science

Year: 2016

Volume: 12

Issue: 2

Pages: 436-447

Print publication date: 01/04/2016

Online publication date: 01/02/2016

Acceptance date: 20/08/2014

ISSN (print): 1734-1922

ISSN (electronic): 1896-9151

Publisher: Termedia

URL: http://dx.doi.org/10.5114/aoms.2016.59271

DOI: 10.5114/aoms.2016.59271

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