Lookup NU author(s): Dr Ricardo Martins Gouveia,
Dr Ana Gouveia Gil,
Professor Che Connon
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).
A new Brillouin spectro-microscope was designed and built to investigate the mechanical properties of bovine and human corneas. This instrument integrates a single-stage virtually imaged phased array spectrometer with a novel adaptive-optics interferometric filter to achieve unprecedented rejection of the elastic background signal. As a result, highly-resolved, reproducible data from both thin and thick collagen-based materials were obtained. In particular, this technique is capable of rigorously measuring the relative stiffness of different areas of human corneas, thus providing a true non-contact method to characterise the fundamental mechanical features of both live and fixed biological tissue samples.
Author(s): Lepert G, Gouveia RM, Connon CJ, Paterson C
Publication type: Article
Publication status: Published
Journal: Faraday Discussions
Print publication date: 01/06/2016
Online publication date: 06/04/2016
Acceptance date: 07/12/2015
ISSN (print): 1359-6640
ISSN (electronic): 1364-5498
Publisher: Royal Society of Chemistry
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