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The role of exosomes in the pathogenesis of pancreatic ductal adenocarcinoma

Lookup NU author(s): Stuart Robinson, Steven White, Richard Charnley, Professor Jelena Mann

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Abstract

Exosomes are small membrane bound vesicles secreted by cancer cells that have a cytosol rich in proteins and nucleic acids which are capable of modulating the phenotype of neighbouring cells which take them up. In this review we explore the mechanisms through which exosomes are able to impact on the pathogenesis of pancreatic ductal cancer through the modulation of tumour formation and development and exploitation of the tumour microenvironment to modulate both the adaptive and innate immune response. In addition we highlight the potential utility of exosomes not only as biomarkers of disease but also as tools to be used in the therapeutic armamentarium against this disease. (C) 2016 Elsevier Ltd. All rights reserved.


Publication metadata

Author(s): Robinson SM, Fan L, White SA, Charnley RM, Mann J

Publication type: Review

Publication status: Published

Journal: International Journal of Biochemistry & Cell Biology

Year: 2016

Volume: 75

Pages: 131-139

Print publication date: 01/06/2016

Online publication date: 24/03/2016

Acceptance date: 21/03/2016

ISSN (print): 1357-2725

ISSN (electronic): 1878-5875

Publisher: PERGAMON-ELSEVIER SCIENCE LTD

URL: http://dx.doi.org/10.1016/j.biocel.2016.03.009

DOI: 10.1016/j.biocel.2016.03.009


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