Lookup NU author(s): Professor Quentin Anstee,
Professor Chris Day
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Genome-wide association studies and candidate gene studies have informed our understanding of factors contributing to the well-recognized interindividual variation in the progression and outcomes of alcoholic liver disease and nonalcoholic fatty liver disease. We discuss the mounting evidence for shared modifiers and common pathophysiological processes that contribute to development of both diseases. We discuss the functions of proteins encoded by risk variants of genes including patatin-like phospholipase domain-containing 3 and transmembrane 6 superfamily member 2, as well as epigenetic factors that contribute to the pathogenesis of alcoholic liver disease and nonalcoholic fatty liver disease. We also discuss important areas of future genetic research and their potential to affect clinical management of patients.
Author(s): Anstee QM, Seth D, Day CP
Publication type: Article
Publication status: Published
Print publication date: 01/06/2016
Online publication date: 10/02/2016
Acceptance date: 20/01/2016
ISSN (print): 0016-5085
ISSN (electronic): 1528-0012
Publisher: W.B Saunders Co.
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