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Poly(ADP-Ribose) Polymerase in Cervical Cancer Pathogenesis Mechanism and Potential Role for PARP Inhibitors

Lookup NU author(s): Dr Ioannis Kotsopoulos, Ali Kucukmetin, Dr Asima Mukhopadhyay, Professor John Lunec, Professor Nicola Curtin

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Abstract

Treatment options for disease recurrence of women treated for locally advanced and advanced cervical cancer are very limited largely palliative chemotherapy. The low efficacy of the currently available drugs raises the need for new targeted agents. Poly(adeno sine diphosphate [ADP]-ribose) polymerase (PARP) inhibitors (PARPi) have emerged as a promising class of chemotherapeutic agents in cancers associated with defects in DNA repair. Their therapeutic potential in cervical cancer is currently being evaluated in 3 ongoing clinical trials. Here we review the available information regarding all the aspects of PARP in cervical intraepithelial neoplasia and invasive cervical cancer, from expression and the mechanism of action to the role of the polymorphisms in the pathogenesis of the disease, as well as the potential of the inhibitors. We finally propose a new unifying theory regarding the role of PARPs in the development of cervical carcinomas.


Publication metadata

Author(s): Kotsopoulos IC, Kucukmetin A, Mukhopadhyay A, Lunec J, Curtin NJ

Publication type: Review

Publication status: Published

Journal: International Journal of Gynecological Cancer

Year: 2016

Volume: 26

Issue: 4

Pages: 763-769

Print publication date: 01/05/2016

Acceptance date: 01/01/1900

ISSN (print): 1048-891X

ISSN (electronic): 1525-1438

Publisher: LIPPINCOTT WILLIAMS & WILKINS

URL: http://dx.doi.org/10.1097/IGC.0000000000000654

DOI: 10.1097/IGC.0000000000000654


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