Lookup NU author(s): Dr Piergiorgio Gentile
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Poly(DL-lactide-co-epsilon-caprolactone) (PLCL) and poly(DL-lactide-co-glycolide) (PLGA) blends of various compositions were prepared. Fractured sections of PLCL/PLGA blends did not evidence phase separation and blend glass transition temperatures suggested some degree of blend compatibility. The elastic modulus showed a negative deviation from the additive law of mixture. Superior biocompatibility in terms of fibroblast NIH 3T3 cell adhesion and proliferation, better mechanical properties, and a more homogeneous phase were obtained with PLCL/PLGA 25/75 blend. Rapid degradation of PLCL phase (4-8 weeks) in PLCL/PLGA 25/75 blend led to a porous structure, which makes it a potential candidate for drug delivery systems.
Author(s): Nardo T, Chiono V, Gentile P, Tabrizian M, Ciardelli G
Publication type: Article
Publication status: Published
Journal: International Journal of Polymetric Materials and Polymetric Biomaterials
Online publication date: 13/04/2016
Acceptance date: 27/02/2016
ISSN (print): 0091-4037
ISSN (electronic): 1563-535X
Publisher: Taylor & Francis Inc.
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