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Poly(DL-lactide-co-ε-caprolactone) and poly(DL-lactide-co-glycolide) blends for biomedical application: Physical properties, cell compatibility, and in vitro degradation behavior

Lookup NU author(s): Dr Piergiorgio Gentile

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Abstract

Poly(DL-lactide-co-epsilon-caprolactone) (PLCL) and poly(DL-lactide-co-glycolide) (PLGA) blends of various compositions were prepared. Fractured sections of PLCL/PLGA blends did not evidence phase separation and blend glass transition temperatures suggested some degree of blend compatibility. The elastic modulus showed a negative deviation from the additive law of mixture. Superior biocompatibility in terms of fibroblast NIH 3T3 cell adhesion and proliferation, better mechanical properties, and a more homogeneous phase were obtained with PLCL/PLGA 25/75 blend. Rapid degradation of PLCL phase (4-8 weeks) in PLCL/PLGA 25/75 blend led to a porous structure, which makes it a potential candidate for drug delivery systems.


Publication metadata

Author(s): Nardo T, Chiono V, Gentile P, Tabrizian M, Ciardelli G

Publication type: Article

Publication status: Published

Journal: International Journal of Polymetric Materials and Polymetric Biomaterials

Year: 2016

Volume: 65

Issue: 14

Pages: 741-750

Online publication date: 13/04/2016

Acceptance date: 27/02/2016

ISSN (print): 0091-4037

ISSN (electronic): 1563-535X

Publisher: Taylor & Francis Inc.

URL: http://dx.doi.org/10.1080/00914037.2016.1163566

DOI: 10.1080/00914037.2016.1163566


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