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Incidence and outcomes for adults diagnosed with acute myeloid leukemia in the north of England: a real world study

Lookup NU author(s): Dr Nicholas Bown, Gavin Cuthbert, Dr David Bourn

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Abstract

We conducted a retrospective population-based study of patients diagnosed with acute myeloid leukemia (AML) in northern England (population 3.1 million) in order to assess the impact of age and genetics on outcome. Four hundred and sixteen patients were diagnosed with AML, between 2007 and 2011. In those aged <= 60 years (n = 20) with acute promyelocytic leukemia (APL) overall survival (OS) was 100%. For non-APL patients aged <= 60 years, OS for those with favorable, intermediate and adverse cytogenetics was not reached, 17 and 9.8 months, respectively (p = 0.0001). Of particular note, intensively treated patients aged >60 years with intermediate cytogenetics and FLT3-/NPM1+ status had a five-year survival of 60% versus median OS of 11 months for other subsets (p = 0.04). Population-based studies reduce selection bias and have utility in studying rarer diseases, particularly in populations that recruit poorly to trials. The highly favorable outcome in our subgroup of intensively-treated FLT3-/NPM1+ older patients merits further study.


Publication metadata

Author(s): McGregor AK, Moulton D, Bown N, Cuthbert G, Bourn D, Mathew S, Dang R, Mounter P, Jones G

Publication type: Article

Publication status: Published

Journal: Leukemia & Lymphoma

Year: 2016

Volume: 57

Issue: 7

Pages: 1575-1584

Print publication date: 01/07/2016

Online publication date: 15/12/2015

Acceptance date: 11/10/2015

ISSN (print): 1042-8194

ISSN (electronic): 1029-2403

Publisher: Taylor & Francis

URL: http://dx.doi.org/10.3109/10428194.2015.1108413

DOI: 10.3109/10428194.2015.1108413


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