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MicroRNAs in Ischemic Heart Disease: From Pathophysiology to Potential Clinical Applications

Lookup NU author(s): Dr Jonathan Batty, Dr Hannah Sinclair, Dr Vijay Kunadian

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Abstract

Despite rapid advances in cardiovascular research and therapeutic strategies, ischemic heart disease (IHD) remains the leading cause of mortality worldwide. MicroRNAs (miRNAs) are small, non-coding RNAs which post-transcriptionally regulate gene expression. In the last few years, miRNAs have emerged as key tools for the understanding of the pathophysiology of IHD, with potential uses as new biomarkers and therapeutic targets. Several studies report a regulatory role of miRNAs, with regard to fundamental components of IHD pathogenesis and progression, such as lipoprotein metabolism, atherogenesis, vascular calcification, platelet function, and angiogenesis. Due to their high stability in biofluids, circulating miRNAs have attracted attention as promising biomarkers of IHD, especially in cardiovascular risk prediction and the diagnosis of myocardial infarction. Furthermore, experimental studies have demonstrated the potential of miRNA-targeted therapy in improving hyperlipidaemia, atherosclerosis, and angiogenesis. In this review, the current knowledge on the role of miRNAs in IHD and translational perspectives of their use are discussed.


Publication metadata

Author(s): Lima J, Batty J, Sinclair H, Kunadian V

Publication type: Review

Publication status: Published

Journal: Cardiology in Review

Year: 2017

Volume: 25

Issue: 3

Pages: 117-125

Print publication date: 01/05/2017

Online publication date: 25/07/2016

Acceptance date: 25/07/2016

ISSN (print): 1061-5377

ISSN (electronic): 1538-4683

URL: http://dx.doi.org/10.1097/CRD.0000000000000114

DOI: 10.1097/CRD.0000000000000114


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