Lookup NU author(s): Professor Andrew Trevelyan
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
All hippocampal and neocortical networks can be driven to seize quite easily. This can be done using drugs, by altering the ionic constituency of the bathing medium [cerebrospinal fluid (CSF)], or by electrical stimulation (both experimentally and clinically, as in electroconvulsive therapy). It is worth asking why this is so, because this will both tell us more about potentially devastating neurological disorders and extend our understanding of cortical function and architecture. Here I review work examining the features of cortical networks that bias activity towards and away from hyperexcitability. I suggest that several cellular- and circuit-level features of rapidly responsive interneuron networks tip the balance away from seizure in the healthy brain.
Author(s): Trevelyan AJ
Publication type: Review
Publication status: Published
Journal: Trends in Neuroscience
Print publication date: 01/08/2016
Online publication date: 01/07/2016
Acceptance date: 01/01/1900
ISSN (print): 0166-2236
ISSN (electronic): 1878-108X
Publisher: ELSEVIER SCIENCE LONDON