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Lookup NU author(s): Dr Silvia Mazzotta
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Understanding heart development is of fundamental importance, because the heart organ is the first functional organ in mammalian embryos and heart function is unremittingly required throughout subsequent life. Earlier cultured stem cell experiments highlighted positive effects of canonical Wnt signaling on subsequent cardiomyocyte differentiation. An early function for Wnt/β-catenin signaling relates to its requirement for mesoderm induction from which cardiac tissue subsequently differentiates. Noncanonical Wnt signaling is clearly a strong stimulator of cardiac specification and subsequent cardiomyocyte differentiation. It has been shown that this effect is mediated by the Wnt/JNK signaling pathway. Translational medicine more recently has focused on the possible lessons to be learned from Wnt signaling mechanisms in embryonic heart development for regeneration of injured heart muscle, for instance, after myocardial infarction.
Author(s): Hoppler S, Mazzotta S, Kuhl M
Editor(s): Hoppler, S; Moon, RT
Publication type: Book Chapter
Publication status: Published
Book Title: Wnt Signaling in Development and Disease: Molecular Mechanisms and Biological Functions
Year: 2014
Print publication date: 05/05/2014
Online publication date: 07/03/2014
Acceptance date: 07/03/2014
Publisher: Wiley-Blackwell Publishing Ltd.
URL: https://doi.org/10.1002/9781118444122.ch22
DOI: 10.1002/9781118444122.ch22
Library holdings: Search Newcastle University Library for this item
ISBN: 9781118444160
