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Selective modulation of cortical state during spatial attention

Lookup NU author(s): Dr Alwin Gieselmann, Professor Alexander Thiele

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This is the authors' accepted manuscript of an article that has been published in its final definitive form by American Association for the Advancement of Science, 2016.

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Abstract

Neocortical activity is permeated with endogenously generated fluctuations, but how these dynamics affect goal-directed behavior remains a mystery. We found that ensemble neural activity in primate visual cortex spontaneously fluctuated between phases of vigorous (On) and faint (Off) spiking synchronously across cortical layers. These On-Off dynamics, reflecting global changes in cortical state, were also modulated at a local scale during selective attention. Moreover, the momentary phase of local ensemble activity predicted behavioral performance. Our results show that cortical state is controlled locally within a cortical map according to cognitive demands and reveal the impact of these local changes in cortical state on goal-directed behavior.


Publication metadata

Author(s): Engel TA, Steinmetz NA, Gieselmann MA, Thiele A, Moore T, Boahen K

Publication type: Article

Publication status: Published

Journal: Science

Year: 2016

Volume: 354

Issue: 6316

Pages: 1140-1144

Print publication date: 02/12/2016

Acceptance date: 31/10/2016

ISSN (print): 0036-8075

ISSN (electronic): 1095-9203

Publisher: American Association for the Advancement of Science

URL: http://dx.doi.org/10.1126/science.aag1420

DOI: 10.1126/science.aag1420


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