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Myxofibrosarcoma of the extremity and trunk

Lookup NU author(s): Dr Petra Dildey, Kenneth Rankin, Tom Beckingsale, Craig Gerrand

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Abstract

AimsMyxofibrosarcomas (MFSs) are malignant soft-tissue sarcomas characteristically presenting as painless slowly growing masses in the extremities. Locally infiltrative growth means that the risk of local recurrence is high. We reviewed our experience to make recommendations about resection strategies and the role of the multidisciplinary team in the management of these tumours.Patients and MethodsPatients with a primary or recurrent MFS who were treated surgically in our unit between 1997 and 2012 were included in the study. Clinical records and imaging were reviewed. A total of 50 patients with a median age of 68.4 years (interquartile range 61.6 to 81.8) were included. There were 35 men; 49 underwent surgery in our unit.ResultsThe lower limb was the most common site (32/50, 64%). The mean size of the tumours was 8.95 cm (1.5 to 27.0); 26 (52%) were French Federation Nationale des Centres de Lutte Contre le Cancer grade III. A total of 21 (43%) had positive margins after the initial excision; 11 underwent further excision. Histology showed microscopic spread of up to 29 mm beyond macroscopic tumour. Local recurrence occurred in seven patients (14%) at a mean of 21 months (3 to 33) and 15 (30%) developed metastases at a mean of 17 months (3 to 30) postoperatively.ConclusionHigh rates of positive margins and the need for further excision makes this tumour particularly suited to management by multidisciplinary surgical teams. Microscopic tumour can be present up to 29 mm from the macroscopic tumour in fascially-based tumours.


Publication metadata

Author(s): Ghazala CG, Agni NR, Ragbir M, Dildey P, Lee D, Rankin KS, Beckingsale TB, Gerrand CH

Publication type: Article

Publication status: Published

Journal: Bone & Joint Journal

Year: 2016

Volume: 98B

Issue: 12

Pages: 1682-1688

Print publication date: 01/12/2016

Online publication date: 01/12/2016

Acceptance date: 08/07/2016

ISSN (print): 2049-4394

ISSN (electronic): 2049-4408

Publisher: British Editorial Society of Bone and Joint Surgery

URL: https://doi.org/10.1302/0301-620X.98B12.37568

PubMed id: 27909132


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