Lookup NU author(s): Dr Petra Dildey,
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AimsMyxofibrosarcomas (MFSs) are malignant soft-tissue sarcomas characteristically presenting as painless slowly growing masses in the extremities. Locally infiltrative growth means that the risk of local recurrence is high. We reviewed our experience to make recommendations about resection strategies and the role of the multidisciplinary team in the management of these tumours.Patients and MethodsPatients with a primary or recurrent MFS who were treated surgically in our unit between 1997 and 2012 were included in the study. Clinical records and imaging were reviewed. A total of 50 patients with a median age of 68.4 years (interquartile range 61.6 to 81.8) were included. There were 35 men; 49 underwent surgery in our unit.ResultsThe lower limb was the most common site (32/50, 64%). The mean size of the tumours was 8.95 cm (1.5 to 27.0); 26 (52%) were French Federation Nationale des Centres de Lutte Contre le Cancer grade III. A total of 21 (43%) had positive margins after the initial excision; 11 underwent further excision. Histology showed microscopic spread of up to 29 mm beyond macroscopic tumour. Local recurrence occurred in seven patients (14%) at a mean of 21 months (3 to 33) and 15 (30%) developed metastases at a mean of 17 months (3 to 30) postoperatively.ConclusionHigh rates of positive margins and the need for further excision makes this tumour particularly suited to management by multidisciplinary surgical teams. Microscopic tumour can be present up to 29 mm from the macroscopic tumour in fascially-based tumours.
Author(s): Ghazala CG, Agni NR, Ragbir M, Dildey P, Lee D, Rankin KS, Beckingsale TB, Gerrand CH
Publication type: Article
Publication status: Published
Journal: Bone & Joint Journal
Print publication date: 01/12/2016
Online publication date: 01/12/2016
Acceptance date: 08/07/2016
ISSN (print): 2049-4394
ISSN (electronic): 2049-4408
Publisher: British Editorial Society of Bone and Joint Surgery
PubMed id: 27909132