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Primary degradation of antidiabetic drugs

Lookup NU author(s): Dr Wojciech Mrozik

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Abstract

Type 2 diabetes is a chronic disease affecting a large portion of the world population and is treated by orally administered drugs. Since these drugs are often taken in high doses and are excreted unchanged or partially metabolised many of them are nowadays detected in surface waters or wastewater treatment plants effluents. Unmetabolised antidiabetics or some of their transformation products retain their pharmacological activity, therefore their presence in the environment is highly undesired. One of the main routes of elimination from wastewaters or surface waters is biodegradation. Within this work we tested primary biodegradation of: metformin and its metabolite guanylurea, acarbose, glibenclamide, gliclazide and glimepiride. We also inspected what might be the extent of the degradation by examining the products formed during the degradation using liquid chromatography coupled to tandem mass spectrometry. Transformation of diabetes staple drug metformin to dead-end product guanylurea was generally confirmed. An alternative, though rather minor pathway leading to complete mineralisation was also found. Complete primary degradation was observed for acarbose, glibenclamide and glimepiride whereas gliclazide was shown to be resistant to biodegradation. These results allow a preliminary assessment of environmental persistency of a very important group of pharmaceuticals and show need for implementing monitoring programs.


Publication metadata

Author(s): Markiewicz M, Jungnickel C, Stolte S, Bialk-Bielinska A, Kumirska J, Mrozik W

Publication type: Article

Publication status: Published

Journal: Journal of Hazardous Materials

Year: 2017

Volume: 324

Issue: Part B

Pages: 428-435

Print publication date: 15/02/2017

Online publication date: 03/11/2016

Acceptance date: 02/11/2016

ISSN (print): 0304-3894

ISSN (electronic): 1873-3336

Publisher: Elsevier Science BV

URL: http://dx.doi.org/10.1016/j.jhazmat.2016.11.008

DOI: 10.1016/j.jhazmat.2016.11.008


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