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Oxidative Stress and Ageing: The Influence of Environmental Pollution, Sunlight and Diet on Skin

Lookup NU author(s): Dr Khimara Naidoo, Professor Mark Birch-Machin

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


Abstract

Skin ageing is a complex process that is determined by both intrinsic and extrinsic factors, which leads to a progressive loss of structure and function. There is extensive evidence indicating that oxidative stress induced by reactive oxygen species plays an important role in the process of human skin ageing. Mitochondria are the major source of cellular oxidative stress and are widely implicated in cutaneous ageing. Extrinsic skin ageing is driven to a large extent by environmental factors and external stressors such as ultraviolet radiation (UVR), pollution and lifestyle factors which have been shown to stimulate the production of reactive oxygen species and generate oxidative stress. The oxidative damage from these exogenous sources can impair skin structure and function, leading to the phenotypic features of extrinsic skin ageing. The following review highlights the current evidence surrounding the role of mitochondria and oxidative stress in the ageing process and the influence of environmental factors such as ultraviolet radiation, pollution and diet on skin ageing.


Publication metadata

Author(s): Naidoo K, Birch-Machin MA

Publication type: Article

Publication status: Published

Journal: Cosmetics

Year: 2017

Volume: 4

Issue: 1

Pages: 1-8

Online publication date: 10/01/2017

Acceptance date: 03/01/2017

Date deposited: 24/02/2017

ISSN (electronic): 2079-9284

Publisher: MDPI

URL: http://dx.doi.org/10.3390/cosmetics4010004

DOI: 10.3390/cosmetics4010004


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