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Anti-inflammatory and analgesic effects of the sesquiterpene lactone budlein A in mice: Inhibition of cytokine production-dependent mechanism

Lookup NU author(s): Dr Henrique De Paula Lemos

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Abstract

The anti-inflammatory activities of some medicinal plants are attributed to their contents of sesquiterpene lactones. In the present study, the anti-inflammatory and anti-nociceptive activity of a sesquiterpene lactone isolated from Viguiera robusta, budlein A in mice was investigated. The treatment with budlein A dose--(1.0-10.0 mg/kg, p.o., respectively) dependently inhibited the carrageenan-induced: i. neutrophil migration to the peritoneal cavity (2-52%), ii. neutrophil migration to the paw skin tissue (32-74%), iii. paw oedema (13-74%) and iv. mechanical hypernociception (2-58%) as well as the acetic acid-induced writhings (0-66%). Additionally, budlein A (10.0 mg/kg) treatment inhibited the mechanical hypernociception-induced by tumour necrosis factor (TNF-alpha, 36%), Keratinocyte-derived chemokine (KC, 37%) and Interleukin-1beta (IL-1beta, 28%), but not of prostaglandin E(2) or dopamine. Budlein A also inhibited the carrageenan-induced release of TNF-alpha (52%), KC (70%) and IL-1beta (59%). Furthermore, an 8 days treatment with budlein A inhibited Complete Freund's adjuvant (10 microl/paw)-induced hypernociception, paw oedema and paw skin myeloperoxidase activity increase while not affecting the motor performance or myeloperoxidase activity in the stomach. Concluding, the present data suggest that budlein A presents anti-inflammatory and antinociceptive property in mice by a mechanism dependent on inhibition of cytokines production. It supports the potential beneficial effect of orally administered budlein A in inflammatory diseases involving cytokine-mediated nociception, oedema and neutrophil migration.


Publication metadata

Author(s): Valério DA, Cunha TM, Arakawa NS, Lemos HP, DaCosta FB, Parada CA, Ferreira SH, Cunha FQ, Verri WAJr

Publication type: Article

Publication status: Published

Journal: European Journal of Pharmacology

Year: 2007

Volume: 562

Issue: 1-2

Pages: 155-163

Print publication date: 07/05/2007

Online publication date: 01/02/2007

ISSN (print): 0014-2999

ISSN (electronic): 1879-0712

Publisher: Elsevier

URL: http://doi.org/10.1016/j.ejphar.2007.01.029

DOI: 10.1016/j.ejphar.2007.01.029

PubMed id: 17320857


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