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Lookup NU author(s): Dr Mark Birch, Dr Kathleen Wright
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A complex array of cellular and molecular events underlies the (patho)physiology of bone and cartilage. Tissue culture approaches have provided great insight into the mechanisms that regulate the activity of bone cells (osteoclasts, osteoblasts, osteocytes) and cartilage cells (chondrocytes). These approaches include assays that have evolved to investigate the differentiation processes of progenitor cells as well as characterising the functionality of mature cells. What has become increasingly apparent is that the three-dimensional environment is an important regulator in the control of cell activity, and tissue culture approaches have been developed to evaluate the role of these substrate-derived cues. © 2013 Woodhead Publishing Limited. All rights reserved.
Author(s): Birch MA, Wright KE
Publication type: Book Chapter
Publication status: Published
Book Title: Standardisation in Cell and Tissue Engineering: Methods and Protocols
Year: 2013
Pages: 54-76
Online publication date: 27/03/2014
Publisher: Elsevier Ltd.
URL: https://doi.org/10.1533/9780857098726.1.54
DOI: 10.1533/9780857098726.1.54
Library holdings: Search Newcastle University Library for this item
ISBN: 9780857094193
