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Phospholipid bilayer nanodiscs: A powerful tool to study the structural organization and biochemical reactivity of proteins in membrane-like environments

Lookup NU author(s): Dr Victor Hernandez-Rocamora

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Abstract

© 2014 Bentham Science Publishers. Nanodiscs are disc-like structures formed by two copies of a membrane scaffold protein, engineered from apolipoprotein A-I, surrounding a phospholipid mixture that can incorporate membrane proteins preserving their natural properties. They behave as soluble entities allowing the use of high-resolution structural techniques to determine the structural organization of the embedded membrane protein, and the use of solution biochemical-biophysical tools to measure its activity, assembly and interactions with other proteins in membranelike environments. In addition, nanodiscs are biocompatible which makes them an attractive technology to be used in therapy, drug discovery, and other biotechnological applications.


Publication metadata

Author(s): Hernandez-Rocamora VM, Garcia-Montanes C, Rivas G

Publication type: Article

Publication status: Published

Journal: Current Topics in Medicinal Chemistry

Year: 2014

Volume: 14

Issue: 23

Pages: 2637-2646

Print publication date: 01/12/2014

Acceptance date: 01/01/1900

ISSN (print): 1568-0266

ISSN (electronic): 1873-4294

Publisher: Bentham Science Publishers BV

PubMed id: 25515754


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