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The properties of the mucus barrier, a unique gel - how can nanoparticles cross it?

Lookup NU author(s): Professor Jeffrey Pearson, Dr Peter Chater, Dr Matthew Wilcox

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Abstract

© 2016 Future Science Ltd. The key criterion for a nanoparticle drug-delivery system is the ability to produce substantial bioavailability without damaging the physiological protective mechanisms. The main area for drug delivery is the aerodigestive tract. All epithelial surfaces have a membrane-bound layer and in the lung this layer is surmounted by a gel layer. In the gastrointestinal tract the membrane-bound mucin layer is covered by a mucus bilayer. The pore sizes of mucus gels are around 100 to 200 nm. Consequently, only nanoparticles in this size range could potentially penetrate without modification of these layers. To study nanoparticle permeation with results that pertain to in vivo conditions, native mucus mucin preparations must be used. Strategies to increase pores in mucus gels are discussed herein.


Publication metadata

Author(s): Pearson JP, Chater PI, Wilcox MD

Publication type: Review

Publication status: Published

Journal: Therapeutic Delivery

Year: 2016

Volume: 7

Issue: 4

Pages: 229-244

Online publication date: 01/04/2016

Acceptance date: 01/01/1900

ISSN (print): 2041-5990

ISSN (electronic): 2041-6008

Publisher: Future Science Ltd

URL: http://doi.org/10.4155/tde-2015-0002

DOI: 10.4155/tde-2015-0002


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