Lookup NU author(s): Dr YuZhu Cheng
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Since its discovery in 1992, the small, 10.4 kDa calcium-binding protein S100P has gained the attention of researchers from different scientific fields due to its potential roles in both healthy and neoplastic tissues. Although not ubiquitously expressed, in tissues where it is present, S100P is associated with distinct changes in cellular behaviour. In this review we have summarized the evolutionary history of S100P, its expression and involvement in implantation and human embryonic development, as well as important functions in normal tissue and cancer. Finally, we have demonstrated its pivotal role as a potential diagnostic and therapeutic target, which opens promising avenues for further fruitful research on S100P.
Author(s): Prica F, Radon T, Cheng Y, Crnogorac-Jurcevic T
Publication type: Review
Publication status: Published
Journal: American Journal of Cancer Research
Print publication date: 01/02/2016
Online publication date: 15/01/2016
Acceptance date: 10/01/2016
ISSN (print): 2156-6976
Publisher: E-Century Publishing Corporation