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Patient-specific 3D hemodynamics modelling of left coronary artery under hyperemic conditions

Lookup NU author(s): Dr Girish Viswanathan


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© 2016 International Federation for Medical and Biological Engineering The purpose of this study is to investigate the effect of various degrees of percentage stenosis on hemodynamic parameters during the hyperemic flow condition. 3D patient-specific coronary artery models were generated based on the CT scan data using MIMICS-18. Numerical simulation was performed for normal and stenosed coronary artery models of 70, 80 and 90% AS (area stenosis). Pressure, velocity, wall shear stress and fractional flow reserve (FFR) were measured and compared with the normal coronary artery model during the cardiac cycle. The results show that, as the percentage AS increase, the pressure drop increases as compared with the normal coronary artery model. Considerable elevation of velocity was observed as the percentage AS increases. The results also demonstrate a recirculation zone immediate after the stenosis which could lead to further progression of stenosis in the flow-disturbed area. Highest wall shear stress was observed for 90% AS as compared to other models that could result in the rupture of coronary artery. The FFR of 90% AS is found to be considerably low.

Publication metadata

Author(s): Kamangar S, Badruddin IA, Govindaraju K, Nik-Ghazali N, Badarudin A, Viswanathan GN, Ahmed NJS, Khan TMY

Publication type: Article

Publication status: Published

Journal: Medical and Biological Engineering and Computing

Year: 2017

Volume: 55

Issue: 8

Pages: 1451-1461

Print publication date: 01/08/2017

Online publication date: 21/12/2016

Acceptance date: 01/12/2016

ISSN (print): 0140-0118

ISSN (electronic): 1741-0444

Publisher: Springer Verlag


DOI: 10.1007/s11517-016-1604-8


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