Toggle Main Menu Toggle Search

Open Access padlockePrints

Repair, Reuse, Recycle: The Expanding Role of Autophagy in Genome Maintenance

Lookup NU author(s): Dr Graeme Hewitt, Dr Viktor Korolchuk

Downloads


Licence

This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


Abstract

© 2016 The Authors. (Macro)Autophagy is a catabolic pathway that delivers excess, aggregated, or damaged proteins and organelles to lysosomes for degradation. Autophagy is activated in response to numerous cellular stressors such as increased levels of reactive oxygen species (ROS) and low levels of cellular nutrients as well as DNA damage. Although autophagy occurs in the cytoplasm, its inhibition leads to accumulation of DNA damage and genomic instability. In the past few years, our understanding of the interplay between autophagy and genomic stability has greatly increased. In this review we summarize these recent advances in understanding the molecular mechanisms linking autophagy to DNA repair. Recent studies have demonstrated the turnover of nuclear components such as nuclear lamina, chromatin, and DNA by autophagy and suggest that it plays an important role in maintaining genomic stability.Loss/inhibition of autophagy gives rise to reduced DNA damage repair and increased cell death in response to genotoxic stress.The accumulation of the autophagy receptor protein p62/SQSTM1 that results from inhibition/loss of autophagy leads to inhibition of double-strand break (DSB) repair through homologous recombination (HR).Recently, progress has been made in unraveling the molecular mechanisms linking p62 and DSB repair. Nuclear p62 dampens HR through the inhibition of RNF168-mediated chromatin ubiquitination as well as targeting the HR proteins RAD51 and filamin A for degradation via the proteasome.


Publication metadata

Author(s): Hewitt G, Korolchuk VI

Publication type: Article

Publication status: Published

Journal: Trends in Cell Biology

Year: 2016

Volume: 27

Issue: 5

Pages: 340-351

Print publication date: 01/05/2017

Online publication date: 21/12/2016

Acceptance date: 02/04/2016

Date deposited: 11/05/2017

ISSN (print): 0962-8924

ISSN (electronic): 1879-3088

Publisher: Elsevier Ltd

URL: http://doi.org/10.1016/j.tcb.2016.11.011

DOI: 10.1016/j.tcb.2016.11.011


Altmetrics

Altmetrics provided by Altmetric


Actions

Find at Newcastle University icon    Link to this publication


Share