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Lookup NU author(s): Kevin McEleny, Professor Timothy Cheetham, Dr Richard Quinton
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© 2017 John Wiley & Sons Ltd Advances in surgical sperm retrieval have greatly increased the chances of men with Klinefelter syndrome achieving biological paternity. Despite this, the vast majority of attempts to achieve fertility by using extracted gametes to fertilize eggs in vitro do not result in viable pregnancies. A powerful obstacle to success lies with the natural history of seminiferous tubule and germ cell function in Klinefelter syndrome, which typically peak (and thereafter steeply decline) up to a decade before most individuals would be contemplating paternity. Herein we discuss, in relation to a real clinical case, both the exciting technical advances surgical sperm retrieval and the logistic and ethical factors that, in practice, may act to limit their successful application.
Author(s): McEleny K, Cheetham T, Quinton R
Publication type: Article
Publication status: Published
Journal: Clinical Endocrinology
Year: 2017
Volume: 86
Issue: 4
Pages: 463-466
Print publication date: 01/04/2017
Online publication date: 27/12/2016
Acceptance date: 21/12/2016
ISSN (print): 0300-0664
ISSN (electronic): 1365-2265
Publisher: Blackwell Publishing Ltd
URL: https://doi.org/10.1111/cen.13298
DOI: 10.1111/cen.13298
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