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Widespread and Opponent fMRI Signals Represent Sound Location in Macaque Auditory Cortex

Lookup NU author(s): Michael Ortiz Rios

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND).


Abstract

© 2017 Elsevier Inc.In primates, posterior auditory cortical areas are thought to be part of a dorsal auditory pathway that processes spatial information. But how posterior (and other) auditory areas represent acoustic space remains a matter of debate. Here we provide new evidence based on functional magnetic resonance imaging (fMRI) of the macaque indicating that space is predominantly represented by a distributed hemifield code rather than by a local spatial topography. Hemifield tuning in cortical and subcortical regions emerges from an opponent hemispheric pattern of activation and deactivation that depends on the availability of interaural delay cues. Importantly, these opponent signals allow responses in posterior regions to segregate space similarly to a hemifield code representation. Taken together, our results reconcile seemingly contradictory views by showing that the representation of space follows closely a hemifield code and suggest that enhanced posterior-dorsal spatial specificity in primates might emerge from this form of coding.


Publication metadata

Author(s): Ortiz-Rios M, Azevedo FAC, Kuśmierek P, Balla DZ, Munk MH, Keliris GA, Logothetis NK, Rauschecker JP

Publication type: Article

Publication status: Published

Journal: Neuron

Year: 2017

Volume: 93

Issue: 4

Pages: 971-983.e4

Print publication date: 22/02/2017

Online publication date: 09/02/2017

Acceptance date: 15/01/2017

Date deposited: 02/05/2017

ISSN (print): 0896-6273

ISSN (electronic): 1097-4199

Publisher: Cell Press

URL: https://doi.org/10.1016/j.neuron.2017.01.013

DOI: 10.1016/j.neuron.2017.01.013


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