Lookup NU author(s): Professor Melissa Bateson,
Professor Daniel Nettle
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© 2016 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd. Longitudinal studies of human leucocyte telomere length often report a percentage of individuals whose telomeres appear to lengthen. However, based on theoretical considerations and empirical data, Steenstrup et al. (Nucleic Acids Research, 2013, vol 41(13): e131) concluded that this lengthening is unlikely to be a real biological phenomenon and is more likely to be an artefact of measurement error. We dispute the logic underlying this claim. We argue that Steenstrup et al.'s analysis is incomplete because it failed to compare predictions derived from assuming a scenario with no true telomere lengthening with alternative scenarios in which true lengthening occurs. To address this deficit, we built a computational model of telomere dynamics that allowed us to compare the predicted percentage of observed telomere length gainers given differing assumptions about measurement error and the true underling dynamics. We modelled a set of scenarios, all assuming measurement error, but both with and without true telomere lengthening. We found a range of scenarios assuming some true telomere lengthening that yielded either similar or better quantitative fits to the empirical data on the percentage of individuals showing apparent telomere lengthening. We conclude that although measurement error contributes to the prevalence of apparent telomere lengthening, Steenstrup et al.'s conclusion was too strong, and current data do not allow us to reject the hypothesis that true telomere lengthening is a real biological phenomenon in epidemiological studies. Our analyses highlight the need for process-level models in the analysis of telomere dynamics.
Author(s): Bateson M, Nettle D
Publication type: Article
Publication status: Published
Journal: Aging Cell
Print publication date: 01/04/2017
Online publication date: 12/12/2016
Acceptance date: 11/11/2016
Date deposited: 31/05/2017
ISSN (print): 1474-9718
ISSN (electronic): 1474-9726
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