Lookup NU author(s): Alvaro Martinez Guimera,
Dr Carole Proctor
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© 2017 The Author(s). The aging process is driven at the cellular level by random molecular damage that slowly accumulates with age. Although cells possess mechanisms to repair or remove damage, they are not 100% efficient and their efficiency declines with age. There are many molecular mechanisms involved and exogenous factors such as stress also contribute to the aging process. The complexity of the aging process has stimulated the use of computational modelling in order to increase our understanding of the system, test hypotheses and make testable predictions. As many different mechanisms are involved, a wide range of models have been developed. This paper gives an overview of the types of models that have been developed, the range of tools used, modelling standards and discusses many specific examples of models that have been grouped according to the main mechanisms that they address. We conclude by discussing the opportunities and challenges for future modelling in this field.
Author(s): McAuley MT, Guimera AM, Hodgson D, McDonald N, Mooney KM, Morgan AE, Proctor CJ
Publication type: Review
Publication status: Published
Journal: Bioscience Reports
Print publication date: 23/02/2017
Online publication date: 17/01/2017
Acceptance date: 16/01/2017
ISSN (print): 0144-8463
ISSN (electronic): 1573-4935
Publisher: Portland Press Ltd
PubMed id: 28096317