Lookup NU author(s): Professor Steve Wedge
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© 2017 Elsevier B.V. In vivo studies in animal models are critical tools necessary to study the fundamental complexity of carcinogenesis. A constant strive to improve animal models in cancer exists, especially those investigating the use of chemotherapeutic effectiveness. In the present systematic review, colorectal cancer (CRC) is used as an example to highlight and critically evaluate the range of reporting strategies used when investigating chemotherapeutic agents in the preclinical setting. A systematic review examining the methodology and reporting of preclinical chemotherapeutic drug studies using CRC murine models was conducted. A total of 45 studies were included in this systematic review. The literature was found to be highly heterogeneous with various cell lines, animal strains, animal ages and chemotherapeutic compounds/regimens tested, proving difficult to compare outcomes between similar studies or indeed gain any significant insight into which chemotherapeutic regimen caused adverse events. From this analysis we propose a minimum core outcome dataset that could be regarded as a standardised way of reporting results from in vivo experimentation.
Author(s): West MA, Roman A, Sayan E, Primrose JN, Wedge SR, Underwood TJ, Mirnezami AH
Publication type: Review
Publication status: Published
Journal: Critical Reviews in Oncology/Hematology
Print publication date: 01/04/2017
Online publication date: 16/02/2017
Acceptance date: 13/02/2017
ISSN (print): 1040-8428
ISSN (electronic): 1879-0461
Publisher: Elsevier Ireland Ltd