Lookup NU author(s): Dr Marta Markiewicz,
Dr Wojciech Mrozik
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© 2017 Elsevier B.V. Hypoglycaemic pharmaceuticals are recently more and more frequently detected in the environment. In our previous study, we have shown that even though many of them undergo significant primary degradation some are transformed to stable products or undergo such transformation that a large part of the structure is still preserved. One of the main routes of elimination from wastewaters or surface waters is biodegradation and a lack thereof leads to accumulation in the environment. Within this work we tested the ultimate biodegradability of six oral antidiabetics: metformin and its main metabolite guanylurea, acarbose, glibenclamide, gliclazide, glimepiride and repaglinide. We also compared the experimental results obtained in this and accompanying work with models designed to predict biodegradability and showed that these models are only moderately successful. Additionally, we examined these compounds in acute Daphnia magna test to check if they might pose an ecotoxicological threat. Combining the results of biodegradability and toxicity tests allows a preliminary assessment of their potential environmental impact.
Author(s): Markiewicz M, Jungnickel C, Stolte S, Bialk-Bielinska A, Kumirska J, Mrozik W
Publication type: Article
Publication status: Published
Journal: Journal of Hazardous Materials
Print publication date: 05/07/2017
Online publication date: 16/03/2017
Acceptance date: 13/03/2017
ISSN (print): 0304-3894
ISSN (electronic): 1873-3336
Publisher: Elsevier BV
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