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Ultimate biodegradability and ecotoxicity of orally administered antidiabetic drugs

Lookup NU author(s): Dr Marta Markiewicz, Dr Wojciech Mrozik

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Abstract

© 2017 Elsevier B.V. Hypoglycaemic pharmaceuticals are recently more and more frequently detected in the environment. In our previous study, we have shown that even though many of them undergo significant primary degradation some are transformed to stable products or undergo such transformation that a large part of the structure is still preserved. One of the main routes of elimination from wastewaters or surface waters is biodegradation and a lack thereof leads to accumulation in the environment. Within this work we tested the ultimate biodegradability of six oral antidiabetics: metformin and its main metabolite guanylurea, acarbose, glibenclamide, gliclazide, glimepiride and repaglinide. We also compared the experimental results obtained in this and accompanying work with models designed to predict biodegradability and showed that these models are only moderately successful. Additionally, we examined these compounds in acute Daphnia magna test to check if they might pose an ecotoxicological threat. Combining the results of biodegradability and toxicity tests allows a preliminary assessment of their potential environmental impact.


Publication metadata

Author(s): Markiewicz M, Jungnickel C, Stolte S, Bialk-Bielinska A, Kumirska J, Mrozik W

Publication type: Article

Publication status: Published

Journal: Journal of Hazardous Materials

Year: 2017

Volume: 333

Pages: 154-161

Print publication date: 05/07/2017

Online publication date: 16/03/2017

Acceptance date: 13/03/2017

ISSN (print): 0304-3894

ISSN (electronic): 1873-3336

Publisher: Elsevier BV

URL: https://doi.org/10.1016/j.jhazmat.2017.03.030

DOI: 10.1016/j.jhazmat.2017.03.030


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