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ISOINDOLINONE INHIBITORS OF THE MDM2-P53 INTERACTION HAVING ANTICANCER ACTIVITY

Lookup NU author(s): Professor David Rees, Professor Bernard Golding, Dr Ian Hardcastle, Dr Celine Cano, Duncan Miller, Professor Martin Noble, Professor Roger Griffin

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Abstract

The invention provides a compound of formula (I): (I) or tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the various substituents are as defined in the claims. Also provided are pharmaceutical compositions containing the compounds of formula (I), processes for making the compounds and the medical uses of the compounds.


Publication metadata

Inventor(s): Chessari G, Howard S, Buck IM, Cons BD, Johnson CN, Holvey RS, Rees DC, St Denis JD, Tamanini E, Golding BT, Hardcastle IR, Cano CF, Miller DC, Noble MEM, Griffin RJ, Osborne JD, Peach J, Lewis A, Hirst KL, Whittaker BP, Watson DR

Publication type: Patent

Publication status: Published

Year: 2017

Print publication date: 06/04/2017

Online publication date: 06/04/2017

Acceptance date: 06/04/2017


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