Toggle Main Menu Toggle Search

Open Access padlockePrints

Gait Rather Than Cognition Predicts Decline in Specific Cognitive Domains in Early Parkinson’s Disease

Lookup NU author(s): Dr Rosie Morris, Dr Susan Lord, Dr Rachael Lawson, Dr Shirley Coleman, Dr Brook Galna, Dr Gordon Duncan, Dr Tien Kheng Khoo, Dr Alison Yarnall, Professor David Burn, Professor Lynn Rochester

Downloads


Licence

This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


Abstract

Background:Dementia is significant in Parkinson’s disease (PD) with personal and socioeconomic impact. Early identification of risk is of upmost importance to optimize management. Gait precedes and predicts cognitive decline and dementia in older adults. We aimed to evaluate gait characteristics as predictors of cognitive decline in newly diagnosed PD.Methods:One hundred and nineteen participants recruited at diagnosis were assessed at baseline, 18 and 36 months. Baseline gait was characterized by variables that mapped to five domains: pace, rhythm, variability, asymmetry, and postural control. Cognitive assessment included attention, fluctuating attention, executive function, visual memory, and visuospatial function. Mixed-effects models tested independent gait predictors of cognitive decline.Results:Gait characteristics of pace, variability, and postural control predicted decline in fluctuating attention and visual memory, whereas baseline neuropsychological assessment performance did not predict decline.Conclusions:This provides novel evidence for gait as a clinical biomarker for PD cognitive decline in early disease.


Publication metadata

Author(s): Morris R, Lord S, Lawson RA, Coleman S, Galna B, Duncan GW, Khoo TK, Yarnall AJ, Burn DJ, Rochester L

Publication type: Article

Publication status: Published

Journal: Journal of Gerontology: Series A

Year: 2017

Volume: 72

Issue: 12

Pages: 1656-1662

Print publication date: 09/11/2017

Online publication date: 03/05/2017

Acceptance date: 07/04/2017

ISSN (print): 1079-5006

ISSN (electronic): 1758-535X

Publisher: Oxford University Press

URL: https://doi.org/10.1093/gerona/glx071

DOI: 10.1093/gerona/glx071


Altmetrics

Altmetrics provided by Altmetric


Actions

Find at Newcastle University icon    Link to this publication


Share