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Lookup NU author(s): Alexander Popov,
Dr Bill Scott,
Dr Jinju Chen,
Professor James Shaw,
Professor Kenneth Dalgarno,
Dr Ana Ferreira-Duarte
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Type-1 diabetes mellitus is defined by the inability to control systemic glucose levels, due to an autoimmune destruction of the insulin-producing β-cells. Treatment involves routine glucose monitoring and insulin infusion. However, some patients with hypoglycaemia unawareness may require pancreas or islet transplantation. Islet transplantation is a minimally invasive 'micro-tissue' therapy aimed at reducing hyperglycaemia and eliminating severe hypoglycaemia. This is achieved by infusing islets of Langerhans into the portal vein; where they engraft in the liver. Major limitations of islet transplantation include the need for life-long immunosuppression and a high tissue demand. This work aims to overcome these restrictions and improve engraftment by applying 3D bioprinting to standardise islet size and ECM composition with the goal to reduce tissue loss immediately post transplantation and improve engraftment. A tri-component ‘bioink’ hydrogel was developed and investigated using collagen, alginate and fibrin (CAF), at three collagen concentrations (0.5%, 1% and 2.5%), for β-cell replacement therapy to treat type-1 diabetes.
Author(s): Popov AA, Montalbano G, Scott WE, Chen J, Shaw JAM, Dalgarno K, Ferreira-Duarte AM
Publication type: Conference Proceedings (inc. Abstract)
Publication status: Published
Conference Name: TERMIS-EU 2016 Conference
Year of Conference: 2016
Online publication date: 28/06/2016
Acceptance date: 01/01/2016