Browse by author
Lookup NU author(s): Professor David BrooksORCiD
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
© 2017 International Parkinson and Movement Disorder Society Background: Alzheimer's disease copathology is common in PD at autopsy. In non-PD subjects with mild cognitive impairment, tau depositions can be detected using 18F-AV-1451 PET. We hypothesized that 18F-AV-1451 PET would show tau aggregation in PD with mild cognitive impairment and correlate with cognitive dysfunction. Objectives: To describe tau aggregation in PD patients. Methods: Twenty-six PD patients and 23 controls had 18F-AV-1451 PET and neuropsychological assessment to detect mild cognitive impairment. Results: Nine PD patients (35%) were identified with mild cognitive impairment. Regional analyses showed no significant differences between groups. Voxel-wise analyses showed no correlation with cognitive domain z-scores within patients. One patient with mild cognitive impairment was estimated Braak tau stage 5; all other patients were stage 0. Conclusion: Our results indicate that tau pathology, as detected by 18F-AV-1451, is uncommon in PD with mild cognitive impairment and shows no significant correlation with cognitive dysfunction at this stage. © 2017 International Parkinson and Movement Disorder Society.
Author(s): Hansen AK, Damholdt MF, Fedorova TD, Knudsen K, Parbo P, Ismail R, Ostergaard K, Brooks DJ, Borghammer P
Publication type: Article
Publication status: Published
Journal: Movement Disorders
Year: 2017
Volume: 32
Issue: 6
Pages: 922-927
Print publication date: 01/06/2017
Online publication date: 03/03/2017
Acceptance date: 27/01/2017
ISSN (print): 0885-3185
ISSN (electronic): 1531-8257
Publisher: John Wiley and Sons Inc.
URL: https://doi.org/10.1002/mds.26961
DOI: 10.1002/mds.26961
Altmetrics provided by Altmetric
