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Design and validation study of a laboratory scale chemical reactor for non-invasive imaging of macro objects in situ

Lookup NU author(s): Chinyelumndu Nwosu, Dr Julie Parker, Dr Francis Franklin, Dr Katarina Novakovic

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


Abstract

Inexpensive in situ monitoring of a conformational change in a macro object over long periods of time in a chemical reactor is challenging. One research area which would benefit from improvements in screening methods is the study of smart hydrogels, particularly when they are intended as oral forms for drug delivery or as multifunctional scaffolds replacing surgically removed tissues. Smart materials have the ability to alter their volume by swelling and/or collapsing in response to a specific stimulus in their environment. Conventional methods used to record this change such as gravimetric analysis, are invasive, require manpower for time-consuming hydrogel handling and often result in material fragmentation leading to inaccuracy. In this work, a novel reactor design is implemented in combination with inexpensive optics to achieve a non-invasive method that can be used reliably over long periods of time. Optical quality flat glass windows are incorporated in a jacketed reactor vessel design to enable undistorted imaging. The reactor was made from a chemical engineering viewpoint to enable temperature control, continuous stirring and sampling while preventing evaporative loss of solvent. Image resolution was measured using a USAF 1951 resolution test target. The setup was validated using pH responsive PVP-Chitosan hydrogels to demonstrate the capabilities of the method in monitoring the change in volume of the responsive hydrogel with time.


Publication metadata

Author(s): Marin D, Fairlie M, Bunton P, Nwosu CN, Parker J, Franklin F, Novakovic K

Publication type: Article

Publication status: Published

Journal: Chemical Engineering Journal

Year: 2017

Volume: 327

Pages: 889-897

Print publication date: 01/11/2017

Online publication date: 01/07/2017

Acceptance date: 01/07/2017

Date deposited: 03/07/2017

ISSN (print): 1385-8947

ISSN (electronic): 1873-3212

Publisher: Elsevier

URL: https://doi.org/10.1016/j.cej.2017.07.001

DOI: 10.1016/j.cej.2017.07.001


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