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Lookup NU author(s): Professor Andrew Blamire
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© 2015 John Wiley & Sons, Ltd. The mammalian brain is highly dependent on adequate cerebral blood flow to supply sufficient substrates to underpin the energetic demands of the tissue. Under conditions of reduced blood flow, cerebral metabolism becomes anaerobic resulting in high levels of lactate production, which can be detected by proton MRS. This article reviews how voxel selected MRS methods can be tailored to detect lactate in vivo in the ischemic brain. The interaction between lactate J-coupling and sequence timing parameters (TE and TM) are discussed, highlighting the strengths and weaknesses of particular approaches for lactate measurement. The biochemical and biological source of the lactate are discussed in the context of interpretation of observations made in clinical studies in brain ischemia and stroke. Finally, some of the main confounding factors for accurate quantitation of brain lactate are considered.
Author(s): Blamire AM
Publication type: Review
Publication status: Published
Online publication date: 15/06/2015
Acceptance date: 01/01/1900
ISSN (electronic): 2055-6101
Publisher: Blackwell Publishing Ltd