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End-Stage Kidney Failure in Oman: An Analysis of Registry Data with an Emphasis on Congenital and Inherited Renal Diseases

Lookup NU author(s): Intisar Al Alawi, Professor John Sayer

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


Abstract

© 2017 Intisar Al Alawi et al. Globally, end-stage kidney disease (ESKD) is a huge burden on health care systems. The aims of this study were to perform a comprehensive epidemiological and etiological report of ESKD patients commencing RRT in Oman with an emphasis on genetic causes and inherited kidney disease. All newly registered Omani patients with ESKD commencing RRT from 2001 until 2015 (n=2,922) were analysed using the RRT register in Oman. All potentially genetic or inherited causes of ESKD were reviewed. In Oman, ESKD is more prevalent in males (57.1%) than females (42.9%) with a median age of incident ESKD of 53 years. Diabetic nephropathy was the most prevalent cause of ESKD (46%), followed by hypertensive nephropathy (19%), glomerulonephritis (15%), and inherited kidney disease (5%). For patients less than 20 years of age inherited kidney disease accounted for 32.5% of cases. Of this cohort with inherited renal disease, 40.3% had autosomal dominant polycystic kidney disease, 11.5% had congenital anomalies of the kidney and urinary tract, 9.4% had Alport syndrome, and 7.2% had autosomal recessive polycystic kidney disease. This study represents a comprehensive population-based epidemiological and etiological report of ESKD patients in Oman commencing RRT. Inherited kidney disease was the leading cause of paediatric ESKD.


Publication metadata

Author(s): Al Alawi I, Al Salmi I, Al Mawali A, Al Maimani Y, Sayer JA

Publication type: Article

Publication status: Published

Journal: International Journal of Nephrology

Year: 2017

Volume: 2017

Online publication date: 08/06/2017

Acceptance date: 16/05/2017

Date deposited: 25/07/2017

ISSN (print): 2090-214X

ISSN (electronic): 2090-2158

Publisher: Hindawi Limited

URL: https://doi.org/10.1155/2017/6403985

DOI: 10.1155/2017/6403985


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