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In vitro degradation of a 3D porous Pennisetum purpureum/PLA biocomposite scaffold

Lookup NU author(s): Professor Geoff Gibson

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Abstract

© 2017 Elsevier LtdThe in vitro degradation and mechanical properties of a 3D porous Pennisetum purpureum (PP)/polylactic acid (PLA)-based scaffold were investigated. In this study, composite scaffolds with PP to PLA ratios of 0%, 10%, 20%, and 30% were immersed in a PBS solution at 37 °C for 40 days. Compression tests were conducted to evaluate the compressive strength and modulus of the scaffolds, according to ASTM F451-95. The compression strength of the scaffolds was found to increase from 1.94 to 9.32 MPa, while the compressive modulus increased from 1.73 to 5.25 MPa as the fillers’ content increased from 0 wt% to 30 wt%. Moreover, field emission scanning electron microscopy (FESEM) and X-ray diffraction were employed to observe and analyse the microstructure and fibre-matrix interface. Interestingly, the degradation rate was reduced for the PLA/PP20 scaffold, though insignificantly, this could be attributed to the improved mechanical properties and stronger fibre-matrix interface. Microstructure changes after degradation were observed using FESEM. The FESEM results indicated that a strong fibre-matrix interface was formed in the PLA/PP20 scaffold, which reflected the addition of P. purpureum into PLA decreasing the degradation rate compared to in pure PLA scaffolds. The results suggest that the P. purpureum/PLA scaffold degradation rate can be altered and controlled to meet requirements imposed by a given tissue engineering application.


Publication metadata

Author(s): Revati R, Majid MSA, Ridzuan MJM, Basaruddin KS, Rahman Y MN, Cheng EM, Gibson AG

Publication type: Article

Publication status: Published

Journal: Journal of the Mechanical Behavior of Biomedical Materials

Year: 2017

Volume: 74

Pages: 383-391

Print publication date: 01/10/2017

Online publication date: 27/06/2017

Acceptance date: 26/06/2017

ISSN (print): 1751-6161

ISSN (electronic): 1878-0180

Publisher: Elsevier Ltd

URL: https://doi.org/10.1016/j.jmbbm.2017.06.035

DOI: 10.1016/j.jmbbm.2017.06.035


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