Lookup NU author(s): Ciaran Welsh,
Dr Glyn Nelson,
Dr Daryl Shanley
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© 2017 The Author(s). Systems modelling has been successfully used to investigate several key molecular mechanisms of ageing. Modelling frameworks to allow integration of models and methods to enhance confidence in models are now well established. In this article, we discuss these issues and work through the process of building an integrated model for cellular senescence as a single cell and in a simple tissue context.
Author(s): Guimera AM, Welsh C, Pezze PD, Fullard N, Nelson G, Roger MF, Przyborski SA, Shanley DP
Publication type: Review
Publication status: Published
Journal: Essays in Biochemistry
Print publication date: 01/07/2017
Online publication date: 11/07/2017
Acceptance date: 25/05/2017
ISSN (print): 0071-1365
Publisher: Portland Press Ltd
PubMed id: 28698310