Browse by author
Lookup NU author(s): Professor Douglas Turkington
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
© 2017 Elsevier B.V. To date, no study has evaluated the effects on brain function of cognitive behavior therapy (CBT) for persistent auditory hallucinations. This study explored the changes in brain activation associated with an emotional auditory paradigm when patients with schizophrenia and auditory hallucinations were treated with CBT. Functional magnetic resonance (fMR) imaging data were obtained from 55 subjects (17 patients with schizophrenia in the therapy group, 24 patients with schizophrenia in the control patient group, and 14 healthy control subjects). The patients in the experimental group were treated with 16-20 bi-weekly sessions of CBT, whereas the patients in the control group received treatment as usual. fMR images were obtained at baseline, 9 and 14. months after enrollment. Patients who received CBT showed significant decrease in brain activation in right and left amygdalae, and the left middle temporal gyrus, compared to both control groups. Significantly reductions in the brain activation of therapy patients were found in both amygdalae, but also in the left superior temporal gyrus and the right superior frontal gyrus at 14-month follow-up. Significant and stable reductions in the abnormal activation of key limbic regions appear to be attributable to the CBT during an emotional auditory paradigm in patients with schizophrenia and persistent auditory hallucinations. These results point to the availability of a biological imaging biomarker for CBT effects in patients with persistent auditory hallucinations.
Author(s): Aguilar EJ, Corripio I, Garcia-Marti G, Grasa E, Marti-Bonmati L, Gomez-Anson B, Sanjuan J, Nunez-Marin F, Lorente-Rovira E, Escarti MJ, Brabban A, Turkington D
Publication type: Article
Publication status: Published
Journal: Schizophrenia Research
Year: 2018
Volume: 193
Pages: 304-312
Print publication date: 01/03/2018
Online publication date: 15/07/2017
Acceptance date: 09/07/2017
ISSN (print): 0920-9964
ISSN (electronic): 1573-2509
Publisher: Elsevier BV
URL: https://doi.org/10.1016/j.schres.2017.07.024
DOI: 10.1016/j.schres.2017.07.024
Altmetrics provided by Altmetric