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Synovial tissue research: A state-of-the-art review

Lookup NU author(s): Professor John Isaacs, Dr Arthur Pratt

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Abstract

© 2017 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. The synovium is the major target tissue of inflammatory arthritides such as rheumatoid arthritis. The study of synovial tissue has advanced considerably throughout the past few decades from arthroplasty and blind needle biopsy to the use of arthroscopic and ultrasonographic technologies that enable easier visualization and improve the reliability of synovial biopsies. Rapid progress has been made in using synovial tissue to study disease pathogenesis, to stratify patients, to discover biomarkers and novel targets, and to validate therapies, and this progress has been facilitated by increasingly diverse and sophisticated analytical and technological approaches. In this Review, we describe these approaches, and summarize how their use in synovial tissue research has improved our understanding of rheumatoid arthritis and identified candidate biomarkers that could be used in disease diagnosis and stratification, as well as in predicting disease course and treatment response.


Publication metadata

Author(s): Orr C, Sousa E, Boyle DL, Buch MH, Buckley CD, Canete JD, Catrina AI, Choy EHS, Emery P, Fearon U, Filer A, Gerlag D, Humby F, Isaacs JD, Just SoA, Lauwerys BR, Le Goff B, Manzo A, McGarry T, McInnes IB, Najm A, Pitzalis C, Pratt A, Smith M, Tak PP, Thurlings R, Fonseca JE, Veale DJ

Publication type: Review

Publication status: Published

Journal: Nature Reviews Rheumatology

Year: 2017

Volume: 13

Issue: 8

Pages: 463-475

Online publication date: 13/07/2017

Acceptance date: 02/04/2016

ISSN (print): 1759-4790

ISSN (electronic): 1759-4804

Publisher: Nature Publishing Group

URL: https://doi.org/10.1038/nrrheum.2017.115

DOI: 10.1038/nrrheum.2017.115


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