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Histamine in diabetes: Is it time to reconsider?

Lookup NU author(s): Dr Ilona Obara, Emma Battell

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND).

Abstract

© 2016 Elsevier Ltd The first studies of histamine and diabetes date back to the 1950s. Since that time the involvement of histamine in diabetes was related to its well known vasoactive properties and permeability leakage effects. In particular, the first evidence for a correlation between histamine and diabetes arose in 1989 when an increase in plasma and leucocyte histamine content was observed. Limited independent evidence followed in the subsequent two decades, focusing on both histamine glyceamic control and macro- and microvascular complications of diabetes. However, recent observations have sparked the question whether it is time to reconsider the functional contribution of histamine in diabetes. We reveal an interesting upsurge in the field which provides scope for new insights into the role of histamine in diabetes.

Publication metadata

Author(s): Pini A, Obara I, Battell E, Chazot PL, Rosa AC

Publication type: Article

Publication status: Published

Journal: Pharmacological Research

Year: 2016

Volume: 111

Pages: 316-324

Print publication date: 01/09/2016

Online publication date: 22/06/2016

Acceptance date: 21/06/2016

Date deposited: 31/01/2019

ISSN (print): 1043-6618

ISSN (electronic): 1096-1186

Publisher: Academic Press

URL: https://doi.org/10.1016/j.phrs.2016.06.021

DOI: 10.1016/j.phrs.2016.06.021

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