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Magnetizable stent-grafts enable endothelial cell capture.

Lookup NU author(s): Dr Jonathan Harburn

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Abstract

Emerging nanotechnologies have enabled the use of magnetic forces to guide the movement of magnetically-labeled cells, drugs, and other therapeutic agents. Endothelial cells labeled with superparamagnetic iron oxide nanoparticles (SPION) have previously been captured on the surface of magnetizable 2205 duplex stainless steel stents in a porcine coronary implantation model. Recently, we have coated these stents with electrospun polyurethane nanofibers to fabricate prototype stent-grafts. Facilitated endothelialization may help improve the healing of arteries treated with stent-grafts, reduce the risk of thrombosis and restenosis, and enable small-caliber applications. When placed in a SPION-labeled endothelial cell suspension in the presence of an external magnetic field, magnetized stent-grafts successfully captured cells to the surface regions adjacent to the stent struts. Implantation within the coronary circulation of pigs (n=13) followed immediately by SPION-labeled autologous endothelial cell delivery resulted in widely patent devices with a thin, uniform neointima and no signs of thrombosis or inflammation at 7 days. Furthermore, the magnetized stent-grafts successfully captured and retained SPION-labeled endothelial cells to select regions adjacent to stent struts and between stent struts, whereas the non-magnetized control stent-grafts did not. Early results with these prototype devices are encouraging and further refinements will be necessary in order to achieve more uniform cell capture and complete endothelialization. Once optimized, this approach may lead to more rapid and complete healing of vascular stent-grafts with a concomitant improvement in long-term device performance.


Publication metadata

Author(s): Tefft BJ, Uthamaraj S, Harburn JJ, Hlinomaz O, Lerman A, Dragomir-Daescu D, Sandhu GS

Publication type: Article

Publication status: Published

Journal: Journal of Magnetism and Magnetic Materials

Year: 2017

Volume: 427

Pages: 100-104

Print publication date: 01/04/2017

Online publication date: 01/11/2016

Acceptance date: 01/10/2016

ISSN (print): 0304-8853

ISSN (electronic): 1873-4766

Publisher: Elsevier B.V.

URL: http://doi.org/10.1016/j.jmmm.2016.11.007

DOI: 10.1016/j.jmmm.2016.11.007


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