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Urolithiasis as an extraarticular manifestation of ankylosing spondylitis

Lookup NU author(s): Professor John SayerORCiD

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Abstract

© 2017 Springer-Verlag GmbH Germany Ankylosing spondylitis (AS) affects sacroiliac and axial joints as well as extraarticular organs, such as the eye, lung, bowel, and heart. Although examples of renal involvement in AS, such as IgA nephropathy, amyloidosis, and glomerulonephritis, have been reported, it has not been emphasized that urolithiasis is frequently formed in the clinical course of AS. Growing evidence indicates that urolithiasis may be observed in AS patients and is more frequent than other extraarticular features. In this review, we will discuss frequency and predictors of AS-related urolithiasis and summarize the possible underlying genetic and biochemical mechanisms. We believe an increased awareness of urolithiasis as a complication of AS will encourage future studies that will shed light on disease mechanisms and preventative therapies.

Publication metadata

Author(s): Korkmaz C, Cansu DU, Sayer JA

Publication type: Article

Publication status: Published

Journal: Rheumatology International

Year: 2017

Volume: 37

Issue: 12

Pages: 1949-1956

Print publication date: 01/12/2017

Online publication date: 18/08/2017

Acceptance date: 07/08/2017

Date deposited: 08/01/2018

ISSN (print): 0172-8172

ISSN (electronic): 1437-160X

Publisher: Springer Verlag

URL: https://doi.org/10.1007/s00296-017-3788-0

DOI: 10.1007/s00296-017-3788-0

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