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Biased numerical cognition impairs economic decision-making in Parkinson's disease

Lookup NU author(s): Professor Nicola Pavese

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND).


Abstract

© 2017 American Neurological Association. Objective: Previous findings suggest a context-dependent bihemispheric allocation of numerical magnitude. Accordingly, we predicted that lateralized motor symptoms in Parkinson's disease (PD), which reflect hemispheric asymmetries, would induce systematic lateralized biases in numerical cognition and have a subsequent influence on decision-making. Methods: In 20 PD patients and matched healthy controls we assessed numerical cognition using a number-pair bisection and random number generation task. Decision-making was assessed using both the dictator game and a validated questionnaire. Results: PD patients with predominant right-sided motor symptoms exhibited pathological biases toward smaller numerical magnitudes and formulated less favorable prosocial choices during a neuroeconomics task (i.e., dictator game). Conversely, patients with left-sided motor symptoms exhibited pathological biases toward larger numerical magnitudes and formulated more generous prosocial choices. Our account of context-dependent hemispheric allocation of numerical magnitude in PD was corroborated by applying our data to a pre-existing computational model and observing significant concordance. Notably, both numerical biasing and impaired decision-making were correlated with motor asymmetry. Interpretation: Accordingly, motor asymmetry and functional impairment of cognitive processes in PD can be functionally intertwined. To conclude, our findings demonstrate context-dependent hemispheric allocation and encoding of numerical magnitude in PD and how biases in numerical magnitude allocation in Parkinsonian patients can correspondingly impair economic decision-making.


Publication metadata

Author(s): Arshad Q, Bonsu A, Lobo R, Fluri A-S, Sheriff R, Bain P, Pavese N, Bronstein AM

Publication type: Article

Publication status: Published

Journal: Annals of Clinical and Translational Neurology

Year: 2017

Pages: 739-748

Print publication date: 01/10/2017

Online publication date: 08/09/2017

Acceptance date: 24/07/2017

Date deposited: 18/10/2017

ISSN (print): 2328-9503

Publisher: Wiley-Blackwell

URL: https://doi.org/10.1002/acn3.449

DOI: 10.1002/acn3.449


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