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Lookup NU author(s): Dr Amy Reeve

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Abstract

© Springer International Publishing 2016. All rights reserved. More than a decade of research has pushed forward our understanding of the changes that occur within neurons in neurodegenerative disease. From a mitochondrial point of view, we now know that mitochondrial DNA, reactive oxygen species, calcium handling, mitochondrial turnover, movement, neuronal localisation and dynamics are important for neuronal survival. It would seem feasible, therefore, that dysfunction in this organelle will have huge implications for the pathogenesis of a number of degenerative diseases. While we still have much to discover and understand with regard to the causes of these diseases, research in the field of mitochondrial dysfunction can only add to our understanding and hopes for therapeutic interventions.


Publication metadata

Author(s): Reeve AK

Editor(s): Reeve A; Simcox E; Duchen M; Turnbull D

Publication type: Book Chapter

Publication status: Published

Book Title: Mitochondrial Dysfunction in Neurodegenerative Disorders: Second Edition

Year: 2016

Pages: 373-376

Print publication date: 21/06/2016

Online publication date: 09/08/2016

Acceptance date: 02/04/2016

Publisher: Springer International Publishing

Place Published: Cham

URL: https://doi.org/10.1007/978-3-319-28637-2_16

DOI: 10.1007/978-3-319-28637-2_16

Notes: 9783319286358 Hardback ISBN

Library holdings: Search Newcastle University Library for this item

ISBN: 9783319286372


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