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An introduction to mitochondria, their structure and functions

Lookup NU author(s): Eve Simcox, Dr Amy Reeve

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Abstract

© Springer International Publishing 2016. All rights reserved. Mitochondria are essential intracellular organelles whose central role in maintaining energy homeostasis places them at the heart of cell integrity, function and survival. As the reliable provision of energy is so fundamental to every aspect of cellular function, mitochondrial dysfunction inevitably has devastating implications for the cell, the tissue and the organism. This is especially critical in the nervous system, where subtle changes in signalling and function can have catastrophic global consequences. Further, as postmitotic cells are heavily dependent on oxidative phosphorylation and are morphologically enormously complex, neurons pose a unique set of challenges for the mitochondrial population that reside within them. Mitochondrial dysfunction has profound consequences for the nervous system and is implicated in a host of neurological and neurodegenerative diseases. The following chapter introduces the form and function of these fascinating organelles and introduces key concepts and vulnerabilities that may underlie their involvement in neurodegenerative conditions. This introduction lays the foundation for the following chapters, which will explore specific aspects of the roles of these organelles in a range of neurodegenerative disease.


Publication metadata

Author(s): Simcox EM, Reeve AK

Editor(s): Reeve AK; Simcox EM; Duchen MR; Turnbull DM

Publication type: Book Chapter

Publication status: Published

Book Title: Mitochondrial Dysfunction in Neurodegenerative Disorders: Second Edition

Year: 2016

Pages: 3-30

Print publication date: 21/06/2016

Online publication date: 09/06/2016

Acceptance date: 02/04/2016

Publisher: Springer International Publishing

Place Published: Cham

URL: https://doi.org/10.1007/978-3-319-28637-2_1

DOI: 10.1007/978-3-319-28637-2_1

Notes: 9783319286358 Hardback ISBN

Library holdings: Search Newcastle University Library for this item

ISBN: 9783319286372


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