Lookup NU author(s): Dr Michael White,
Professor James Shaw,
Professor Roy Taylor
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The reversible nature of early type 2 diabetes has been demonstrated in in vivo human studies. Recent in vivo and in vitro studies of beta-cell biology have established that the beta-cell loses differentiated characteristics, including glucose-mediated insulin secretion, under metabolic stress. Critically, the beta-cell dedifferentiation produced by long-term excess nutrient supply is reversible. Weight loss in humans permits restoration of first-phase insulin secretion associated with the return to normal of the elevated intrapancreatic triglyceride content. However, in type 2 diabetes of duration greater than 10 years, the cellular changes appear to pass a point of no return. This review summarizes the evidence that early type 2 diabetes can be regarded as a reversible beta-cell response to chronic positive calorie balance.
Author(s): White MG, Shaw JAM, Taylor R
Publication type: Article
Publication status: Published
Journal: Diabetes Care
Print publication date: 01/11/2016
Online publication date: 13/09/2016
Acceptance date: 23/08/2016
ISSN (print): 0149-5992
ISSN (electronic): 1935-5548
Publisher: American Diabetes Association
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