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Type 2 Diabetes: The Pathologic Basis of Reversible β-Cell Dysfunction

Lookup NU author(s): Dr Michael White, Professor James Shaw, Professor Roy Taylor

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This is the authors' accepted manuscript of an article that has been published in its final definitive form by American Diabetes Association, 2016.

For re-use rights please refer to the publisher's terms and conditions.


Abstract

The reversible nature of early type 2 diabetes has been demonstrated in in vivo human studies. Recent in vivo and in vitro studies of beta-cell biology have established that the beta-cell loses differentiated characteristics, including glucose-mediated insulin secretion, under metabolic stress. Critically, the beta-cell dedifferentiation produced by long-term excess nutrient supply is reversible. Weight loss in humans permits restoration of first-phase insulin secretion associated with the return to normal of the elevated intrapancreatic triglyceride content. However, in type 2 diabetes of duration greater than 10 years, the cellular changes appear to pass a point of no return. This review summarizes the evidence that early type 2 diabetes can be regarded as a reversible beta-cell response to chronic positive calorie balance.


Publication metadata

Author(s): White MG, Shaw JAM, Taylor R

Publication type: Article

Publication status: Published

Journal: Diabetes Care

Year: 2016

Volume: 39

Issue: 11

Pages: 2080-2088

Print publication date: 01/11/2016

Online publication date: 13/09/2016

Acceptance date: 23/08/2016

Date deposited: 03/12/2019

ISSN (print): 0149-5992

ISSN (electronic): 1935-5548

Publisher: American Diabetes Association

URL: https://doi.org/10.2337/dc16-0619

DOI: 10.2337/dc16-0619


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